|
KMID : 0386319850180010063
|
|
Korean Leprosy Bulletin
1985 Volume.18 No. 1 p.63 ~ p.67
|
|
|
Purine Nucleoside Phorphorylase Activities in Lymphocytes of Leprosy patients
|
|
金永杓/Ynmg Pio Kim
崔有燮/朴敬濟/田寅淇/Yoo Seop Choi/Kyung Jae Park/Im Ki Chun
|
|
|
Abstract
|
|
|
Purine nucleoside phosporylase (E.C. 2.4.2.1, PNPkse) is an enzyme, which catalyzes the
conversion of purine nucleoside to the free purine bases and found in most human
tissues. A role for PNPase in the immune response has been suggested by the findings
that the enzyme is deficient in the lymphocytes of the patient s with normal T-cell
immunity and defective B-cell immunity.
Enormous studies has been carried out in recent years in clarifying the nature of the
immune response throughout the clinical spectrum of leprosy. It is clearly demonstrated
that persons who develop lepromatous or other low-resistance types of leprosy are
defective of cellular immunity to M ycobacterium leprae (M. leprae), while persons who
develop tuberculoil or high-resistance leprosy gibe specific cellular responses which
appear to normal. Nevertheless, the fact that most people are resistance to M. leprae
and not manifesting leprosy suggests that there is some immunologic deficiency even in
the tuberculoid leprosy.
The present study was designed to determine the PNPase level in lymphocytes from
patients with tuberculoid and lepromatous leprosy. The results indicated that decreased
PNPase levels occur in leprosy, especially in lepromatous leprosy.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|